Ana Maria Cuervo, M.D., Ph.D.
Professor at The albert einstein college of medicine, Robert and Rene Belfer Chair for the Study of Neurodegenerative Diseases
Dr. Ana Maria Cuervo is the Robert and Renee Belfer Chair for the Study of Neurodegenerative Diseases, Professor in the Departments of Developmental and Molecular Biology and of Medicine of the Albert Einstein College of Medicine and co-director of the Einstein Institute for Aging Studies. She obtained her M.D. and Ph.D. in Biochemistry and Molecular Biology from the University of Valencia (Spain) in 1990 and 1994, respectively, and received postdoctoral training at Tufts University, Boston. In 2002, she started her laboratory at the Albert Einstein College of Medicine, where she continues her studies in the role of protein-degradation in neurodegenerative diseases and aging.
Dr. Cuervo’s group is interested in understanding how altered proteins can be eliminated from the cells through the lysosomal system (autophagy) and how the malfunction of autophagy in aging is linked to age-related disorders including neurodegenerative and metabolic diseases.
Autophagy and its Malfunction. Dr. Cuervo aims to understand the role that autophagic pathways have in maintenance of cellular homeostasis, quality control and cellular energetics. Cuervo’s lab is using cellular and experimental mouse models to study how autophagic processes are regulated and what are the consequences of their failure in old organisms.
Cuervo hypothesizes that sustained functional challenges (metabolic excess, presence of toxic proteins, etc) can inhibit autophagic function and that conversely, a decline in autophagic function can promote chronic maladaptation in aging, thereby creating a vicious cycle that amplifies the risk for age-related disorders such as neurodegenerative diseases or metabolic derangements.
If Cuervo’s hypothesis is correct, interventions aimed at preventing or reverting the autophagic failure could have a great therapeutic potential against age-related diseases.
Awards and Honors
P. Benson Award, Keith Porter Fellow, Nathan Shock Memorial Lecture Award, Vincent Cristofalo Award in Aging, Bennett J. Cohen award in basic aging biology, Marshall Horwitz Prize for excellence in research and the Saul Korey Prize in Translational in Medicine Science. LaDonne Schulman Teaching Award (X2) .
Dr. Cuervo has delivered the NIH Director’s Lecture, the SEBBM L’Oreal-UNESCO for Women in Science Lecture and many others.
She is currently co-Editor-in-Chief of Aging Cell. Dr. Cuervo has served at the NIA Scientific Council and the NIH Council of Councils and is currently member of the NIA Board of Scientific Counselors and of the Advisory Committee to the NIH Deputy Director. In 2015, she was elected International Academic of the Royal Academy of Medicine of the Valencia Community and in 2017, she was elected member of the Real Academia de Ciencias Exactas, Fisicas y Naturales. She is also a recently elected member of the American Academy of Arts and Sciences.
aging critical publications
Kaushik S, Cuervo AM. Proteostasis and aging. Nat Med. 21:1406-15, 2015.
Caballero B, Wang Y, Diaz A, Tasset I, Juste YR, Mandelkow E-, Mandelkow E, Cuervo AM*. Interplay of pathogenic forms of human tau with different autophagic pathways. Aging Cell 17(1): doi: 10.2222/acel.12692, 2017 PMID: 29024336
Bejarano E, Murray J, Wang X, Pampliega, O, Yin D, Patel B, Yuste A, Wolkoff A, Cuervo AM. Defective recruitment of motor proteins to autophagic compartments contributes to autophagic failure in aging. Aging Cell doi: 10.1111/acel.12777, 2018
Walter RO, Arias E, Diaz A, Burgos ES, Guan F, Tiano S, Mao K, Green CL, Oiu Y, Shah H, wang D, Hudgins AD, Tabrizian T, Tosti V, Shechter D, Fontana L, Kurland IJ, Barizilai N, Cuervo AM, Promislow DEL, Huffman DM. Sarcosine Is Uniquely Modulated by Aging and Dietary Restriction in Rodents and Humans. Cell Reports 25, P663-676, 2018
Kaushik K, Cuervo AM. The coming of age of Chaperone-mediated autophagy. Nat. Rev. Cell. Mol. Biol. Doi: doi.org/10.1038/s41580-018-0001-6, 2018
Cuervo, A.M.; Dice, J.F. Age-related decrease in chaperone-mediated autophagy. J. Biol. Chem 275, 31505-31513, 2000.
Zhang, C., Cuervo, AM*. Restoration of chaperone-mediated autophagy in aging improves cellular maintenance and organ function. Nat. Med. 14: 959-65, 2008
Anguiano J, Gaerner T, Daas B, Gavathiotis E, Cuervo AM*. Chemical modulation of Chaperone-mediated autophagy by novel retinoic acid derivatives. Nat. Chem. Biol. 9:374-82, 2013
Schneider JL, Suh Y, Cuervo AM*. Deficient chaperone-mediated autophagy in liver leads to metabolic disregulation. Cell Metab. 20:417-432, 2014