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Aging is an inevitable universal trait shared by all humans. Being able to determine and understand the fundamental cellular and molecular processes underlying aging is critical if we want to address the mounting healthcare needs of the growing aged population.
— Pr Juan Carlos Izpisua Belmonte, Ph.D.



Pr. Juan Carlos Izpisua Belmonte, Ph.D.

Professor Gene Expression Laboratory Roger Guillemin Chair, DIRECTOR OF THE DEVELOPMENT AND STEM CELLS BIOLOGY LABORATORIES AT THE SALK INSTITUTE

Professor. Juan Carlos Izpisua Belmonte, PhD serves as Director of the Development and Stem Cells Biology Laboratories at the Salk Institute for Biological Studies, La Jolla, California, USA. Prof. Belmonte is a Research Professor of the Spanish Research Council (CSIC) and the American Heart Association. He has been President of Scientific Advisiory Board at BIOBIDE,S.L since 2004 and also serves as its Member of Scientific Advisiory Board. Since 2004, has been the Director of the Center of Regenerative Medicine in Barcelona. He served as a Member of the Scientific Advisory Board at Genetrix SL. He has the responsibility of been part of the Scientific Journal Editorial Board Member er of several journals, as BMC Developmental Biology, Development, Developmental Biology, Development Genes & Evolution, Development Growth and Differentiation, International Journal of Developmental Biology and Mechanisms of Development.

He went to The Salk Institute of California (San Diego) as assistant professor in 1993 and nowadays is a Professor in this research center, where he directs a laboratory and they are working with the zebra fish as research s model organism. During his professional life he has received several honors/awards like the National Science Foundation Creativity Award in 1999, American Heart Association Established Investigator Award in 2000 and the Medal from the Spanish College of Pharmacy in 2006. He holds MSc. (with Honors). In Pharmacology and PhD in Biochemistry and Pharmacology, with a postdoctoral fellow in the University of Marburg, Germany and another postdoctoral fellow in the European Molecular Biology Laboratories (EMBL), Germany.

FOCUS AREAS

Juan Carlos Izpisua Belmonte rolls back cells’ development to a pluripotent state by improving the methodologies originally described in 2006. In addition, he follows new, more flexible strategies with the goal of providing safer and higher quality products for regenerative medicine. Izpisua Belmonte has spearheaded the development of new techniques to switch cells from one type—such as skin cells—to another type, from blood to brain to kidney, all the while eliminating the need for pluripotent cells. Most notably, Izpisua Belmonte has translated reprogramming technologies to encourage regeneration in living animals in order to, for example, heal infarcted hearts without cell transplantation. All these methods pave the way for stem cell therapies for a plethora of conditions.

Izpisua Belmonte has also created new ways to alter the genes inside stem cells, potentially allowing researchers to create personalized, “corrected” cells that can be transplanted into a patient to cure inherited disease. He showed the approach works with diseases, including premature aging syndromes, blood disorders and Parkinson’s disease. The platforms generated by Izpisua Belmonte could be used to correct countless other mutations in stem cell lines and treat other genetic disorders.

aging critical publications

  • Hatnaka et al. Keeping the Rhythm while Changing the Lyrics: Circadian Biology in Aging. Cell 2017

  • Ocampo et al. In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming. Cell 2016

  • Suzuki et al. In vivo genome editing via CRISPR/Cas9 mediated homology-independent targeted integration. Nature 2016


  • Zhang et al. Aging stem cells. A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging. Science 2015 

  • Liu et al. Recapitulation of premature ageing with iPSCs from Hutchinson-Gilford progeria syndrome. Nature 2011